Article
Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009
Krüger Bernd, Krick Stefanie, Dhillon Navdeep, Lerner Susan M, Ames Scott, Bromberg Jonathan S, Lin Marvin, Walsh Liron, Vella John, Fischereder Michael, Krämer Bernhard K, Colvin Robert B, Heeger Peter S, Murphy Barbara T, Schröppel Bernd
Abstract excerpt
While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft injury in human kidney transplants is unknown. Here we show that TLR4 is constitutively expressed within all donor kidneys but is significantly higher in deceased-, compared with living-donor organs. Tubules from deceased- but not...
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