Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.

doi:10.1007/s10038-007-0186-6

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Article

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.

Journal of human genetics - 1 Jan 2007

Maekawa Keiko, Saeki Mayumi, Saito Yoshiro, Ozawa Shogo, Kurose Kouichi, Kaniwa Nahoko, Kawamoto Manabu, Kamatani Naoyuki, Kato Ken, Hamaguchi Tetsuya, Yamada Yasuhide, Shirao Kuniaki, Shimada Yasuhiro, Muto Manabu, Doi Toshihiko, Ohtsu Atsushi, Yoshida Teruhiko, Matsumura Yasuhiro, Saijo Nagahiro, Sawada Jun-Ichi

Abstract excerpt

Dihydropyrimidine dehydrogenase (DPD) is an inactivating and rate-limiting enzyme for 5-fluorouracil (5-FU), and its deficiency is associated with a risk for developing a severe or fatal toxicity to 5-FU. In this study, to search for genetic variations of DPYD encoding DPD in Japanese, the putative promoter region, all exons, and flanking introns of DPYD were sequenced from 341 subjects including cancer patients...

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Identifiers

PMID: 17828463
DOI: 10.1007/s10038-007-0186-6

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DPYD

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Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.PMID 17828463Read ↗

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