Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.

Blood - 12 Mar 2009

Brodin Petter, Lakshmikanth Tadepally, Johansson Sofia, Kärre Klas, Höglund Petter

Abstract excerpt

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I. If self-MHC is down-regulated or absent, lack of inhibition triggers "missing self" killing. NK cells developing in the absence of MHC class I are hypo-responsive, demonstrating that MHC class I molecules are required for NK-cell education. Here, we show that the number and the type of MHC class I alleles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytotoxicity, Immunologic
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to Killer Cells, Natural

Share to Lymphocyte Activation

Share to Mice, Transgenic

Share to Receptors, KIR

Share to Self Tolerance

Source

Identifiers

PMID: 18974374
DOI: 10.1182/blood-2008-05-156836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.PMID 18974374Read ↗

Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules.Semantic proximity Read ↗

Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned.Semantic proximity Read ↗

Tuning of human NK cells by endogenous HLA-C expression.Semantic proximity Read ↗

Human NK cell education by inhibitory receptors for MHC class I.Semantic proximity Read ↗

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.Semantic proximity Read ↗

MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response.Semantic proximity Read ↗

Origins of natural killer cell memory: special creation or adaptive evolution.Semantic proximity Read ↗

NK-cell education is shaped by donor HLA genotype after unrelated allogeneic hematopoietic stem cell transplantation.Semantic proximity Read ↗

Licensing of natural killer cells by host major histocompatibility complex class I molecules.Semantic proximity Read ↗

Cognate HLA absence in trans diminishes human NK cell educationSemantic proximity Read ↗

Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.Semantic proximity Read ↗

NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.