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Article

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.

Blood - 12 Mar 2009

Brodin Petter, Lakshmikanth Tadepally, Johansson Sofia, Kärre Klas, Höglund Petter

Abstract excerpt

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I. If self-MHC is down-regulated or absent, lack of inhibition triggers "missing self" killing. NK cells developing in the absence of MHC class I are hypo-responsive, demonstrating that MHC cla...

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Share to Cytotoxicity, Immunologic
Share to Down-Regulation
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lymphocyte Activation

Share to Mice, Transgenic

Share to Receptors, KIR

Share to Self Tolerance

Source

Identifiers

PMID: 18974374
DOI: 10.1182/blood-2008-05-156836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18974374-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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