Article
NK-cell education is shaped by donor HLA genotype after unrelated allogeneic hematopoietic stem cell transplantation.
Blood - 20 Jan 2011
Haas Philippe, Loiseau Pascale, Tamouza Ryad, Cayuela Jean-Michel, Moins-Teisserenc Hélène, Busson Marc, Henry Guylaine, Falk Christine S, Charron Dominique, Socié Gérard, Toubert Antoine, Dulphy Nicolas
Abstract excerpt
The rules governing natural killer (NK)-cell education in the allogeneic environment created by unrelated hematopoietic stem-cell transplantation (HSCT) are still largely elusive, especially in an unrelated donor setting. NK-cell inhibitory receptors for self-human leukocyte antigen (HLA) play a central role in the acquisition or maintenance of NK-cell functional competence. Therefore, the responsiveness of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
