Article
NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2014
Sleiman Marwan, Brons Nicolaas H C, Kaoma Tony, Dogu Figen, Villa-Forte Alexandra, Lenoble Patrick, Hentges François, Kotsch Katja, Gadola Stephan D, Vilches Carlos, Zimmer Jacques
Abstract excerpt
The interaction between clonally distributed inhibitory receptors and their activating counterparts on NK cells and HLA class I molecules defines NK cell functions, but the role of HLA class I ligands in the acquisition of their receptors during NK development is still unclear. Although some studies demonstrated that HLA-C affects the expression of killer Ig-like receptors (KIR), other studies showed that NK...
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