Article
Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.
PLoS biology - 1 Aug 2016
Freund Jacquelyn, May Rebecca M, Yang Enjun, Li Hongchuan, McCullen Matthew, Zhang Bin, Lenvik Todd, Cichocki Frank, Anderson Stephen K, Kambayashi Taku
Abstract excerpt
It has recently been appreciated that NK cells exhibit many features reminiscent of adaptive immune cells. Considerable heterogeneity exists with respect to the ligand specificity of individual NK cells and as such, a subset of NK cells can respond, expand, and differentiate into memory-like cells in a ligand-specific manner. MHC I-binding inhibitory receptors, including those belonging to the Ly49 and KIR...
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