Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned.

Trends in immunology - 1 Mar 2018

Boudreau Jeanette E, Hsu Katharine C

Abstract excerpt

The functional capacities of natural killer (NK) cells differ within and between individuals, reflecting considerable genetic variation. 'Licensing/arming', 'disarming', and 'tuning' are models that have been proposed to explain how interactions between MHC class I molecules and their cognate inhibitory receptors - Ly49 in mice and KIR in humans - 'educate' NK cells for variable reactivity and sensitivity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cytotoxicity, Immunologic
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Immune System Diseases

Share to Killer Cells, Natural

Share to Lymphocyte Activation

Share to Receptors, KIR

Source

Open in PubMed Open full text

Identifiers

PMID: 29397297
DOI: 10.1016/j.it.2017.12.001
PMCID: PMC6013060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned.PMID 29397297Read ↗

Tuning of human NK cells by endogenous HLA-C expression.Semantic proximity Read ↗

Ly49 receptors: evolution, genetic diversity, and impact on immunity.Semantic proximity Read ↗

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.Semantic proximity Read ↗

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.Semantic proximity Read ↗

The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus ControlSemantic proximity Read ↗

KIR: diverse, rapidly evolving receptors of innate and adaptive immunity.Semantic proximity Read ↗

Origins of natural killer cell memory: special creation or adaptive evolution.Semantic proximity Read ↗

Regulation of natural killer cell function.Semantic proximity Read ↗

Human NK cells and cancerSemantic proximity Read ↗

Class I HLA haplotypes form two schools that educate NK cells in different waysSemantic proximity Read ↗

HLA alleles determine differences in human natural killer cell responsiveness and potency.Semantic proximity Read ↗

Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMVSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.