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Cognate HLA absence in trans diminishes human NK cell education

28 Aug 2016

Abstract excerpt

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA- tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells...

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PMID: 27571408
DOI: 10.1172/jci86923

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