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Article

A novel method of dynamic culture surface expansion improves mesenchymal stem cell proliferation and phenotype.

Stem cells (Dayton, Ohio) - 1 Jan 2009

Majd Hicham, Wipff Pierre-Jean, Buscemi Lara, Bueno Manuel, Vonwil Daniel, Quinn Thomas M, Hinz Boris

Abstract excerpt

Repeated passaging in conventional cell culture reduces pluripotency and proliferation capacity of human mesenchymal stem cells (MSC). We introduce an innovative cell culture method whereby the culture surface is dynamically enlarged during cell proliferation. This approach maintains constantly high cell density while preventing contact inhibition of growth. A highly elastic culture surface was enlarged in steps...

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Identifiers

PMID: 18974211
DOI: 10.1634/stemcells.2008-0674

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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