Article

A chemically defined biomimetic surface for enhanced isolation efficiency of high-quality human mesenchymal stromal cells under xeno-/serum-free conditions

2021-12-10

Abstract excerpt

Mesenchymal stromal cells (MSCs) are one of the most frequently used cell types in regenerative medicine and cell therapy. Generating sufficient cell numbers for MSC-based therapies is constrained by: 1) their low abundance in tissues of origin, which imposes the need for significant ex vivo cell amplification, 2) donor-specific characteristics including MSC frequency/quality that decline with disease state and in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed1ab078-5fba-59aa-ae50-1e961fe23efc
DOI: 10.1101/2021.12.10.472047

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A chemically defined biomimetic surface for enhanced isolation efficiency of high-quality human mesenchymal stromal cells under xeno-/serum-free conditionsDOI 10.1101/2021.12.10.472047Read

A chemically defined biomimetic surface for enhanced isolation efficiency of high-quality human mesenchymal stromal cells under xenogeneic/serum-free conditionsSemantic proximity Read

Biomimetic Culture Strategies for the Clinical Expansion of Mesenchymal Stromal Cells.Semantic proximity Read

Development and characterization of a clinically compliant xeno-free culture medium in good manufacturing practice for human multipotent mesenchymal stem cells.Semantic proximity Read

Optimizing Mesenchymal Stromal Cells Delivery: Present Status and New Frontiers in Regenerative MedicineSemantic proximity Read

Serum and xeno‐free, chemically defined, no‐plate‐coating‐based culture system for mesenchymal stromal cells from the umbilical cordSemantic proximity Read

High Throughput Morphological Screening Identifies Chemically Defined Media for Mesenchymal Stromal Cells that Enhances Proliferation and Supports Maintenance of Immunomodulatory FunctionSemantic proximity Read

Mesenchymal Stem Cells for Therapeutic PurposesSemantic proximity Read

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency.Semantic proximity Read

Quality assessment of a serum and xenofree medium for the expansion of human GMP-grade mesenchymal stromal cells.Semantic proximity Read

E7-Modified Substrates to Promote Adhesion and Maintain Stemness of Mesenchymal Stem Cells.Semantic proximity Read

Engineering Stem Cells for Biomedical ApplicationsSemantic proximity Read

Concise Review: No Breakthroughs for Human Mesenchymal and Embryonic Stem Cell Culture: Conditioned Medium, Feeder Layer, or Feeder‐Free; Medium with Fetal Calf Serum, Human Serum, or Enriched Plasma; Serum‐Free, Serum Replacement Nonconditioned Medium, or Ad Hoc Formula? All That Glitters Is Not Gold!Semantic proximity Read