Article

Alternating 2D and 3D Culture Reduces Cell Size and Extends the Lifespan of Placenta-Derived MSCs

2025-05-25

Abstract excerpt

Mesenchymal stem cells (MSCs) offer significant therapeutic potential, but traditional 2D culture on rigid substrates results in progressive cell enlargement and senescence, reducing proliferative capacity and therapeutic potency. This poses a major challenge for widespread clinical application. We explored a novel strategy for placenta-derived MSCs combining 2D expansion with 3D spheroid culture to address these...

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Literature Corpus work: 9b971117-0a3e-562c-8e2a-88fb0c58c4d4
DOI: 10.1101/2025.05.20.655182

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