Article
Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency.
Nature materials - 17 Jul 2011
McMurray Rebecca J, Gadegaard Nikolaj, Tsimbouri P Monica, Burgess Karl V, McNamara Laura E, Tare Rahul, Murawski Kate, Kingham Emmajayne, Oreffo Richard O C, Dalby Matthew J
Abstract excerpt
There is currently an unmet need for the supply of autologous, patient-specific stem cells for regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by the material/cell interface suggesting a unique strategy to manipulate stem cells in the absence of complex soluble chemistries or cellular reprogramming. However, so far the derivation and identification of surfaces that allow...
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