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Article

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity.

Hypertension (Dallas, Tex. : 1979) - 1 May 2006

Seasholtz Tammy M, Wessel Jennifer, Rao Fangwen, Rana Brinda K, Khandrika Srikrishna, Kennedy Brian P, Lillie Elizabeth O, Ziegler Michael G, Smith Douglas W, Schork Nicholas J, Brown Joan Heller, O'Connor Daniel T

Abstract excerpt

The Rho/Rho kinase (ROCK) pathway is implicated in experimental hypertension. We, therefore, explored the role of ROCK2 genetic variation in human blood pressure (BP) regulation, exploiting the advantages of a human twin sample to probe heritability. The focus of this work is the common nonsynonymous variant at ROCK2: Thr431Asn. Cardiovascular and autonomic traits displayed substantial heritability (from...

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Identifiers

PMID: 16585408
DOI: 10.1161/01.HYP.0000217364.45622.f0

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ROCK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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