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Article

Allosteric mutants show that PrfA activation is dispensable for vacuole escape but required for efficient spread and Listeria survival in vivo.

Molecular microbiology - 1 Aug 2012

Deshayes Caroline, Bielecka Magdalena K, Cain Robert J, Scortti Mariela, de las Heras Aitor, Pietras Zbigniew, Luisi Ben F, Núñez Miguel Ricardo, Vázquez-Boland José A

Abstract excerpt

The transcriptional regulator PrfA controls key virulence determinants of the facultative intracellular pathogen Listeria monocytogenes. PrfA-dependent gene expression is strongly induced within host cells. While the basis of this activation is unknown, the structural homology of PrfA with the cA...

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Identifiers

PMID: 22646689
DOI: 10.1111/j.1365-2958.2012.08121.x
PMCID: PMC3443378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22646689-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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