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Article

Mannan-binding lectin genotypes and genotype-phenotype relationships in a large cohort of Polish neonates.

Human immunology - 1 Jan 2009

Swierzko Anna St, Szala Agnieszka, Cedzynski Maciej, Domzalska-Popadiuk Iwona, Borkowska-Klos Monika, Jopek Aleksandra, Szczapa Jerzy, Szemraj Janusz, Atkinson Anne P M, MacDonald Shirley L, Turner Marc L, Kilpatrick David C

Abstract excerpt

Circulating mannan (or mannose)-binding lectin (MBL) is genetically determined. Low MBL concentrations are associated with certain point mutations in the human MBL2 gene. Here we report the full MBL2 genotypes of 1800 Polish neonates and relate individual genotypes to serum MBL and MBL-dependent activity of the lectin pathway of complement activation. The seven acknowledged common haplotypes were found, plus the...

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Identifiers

PMID: 18957309
DOI: 10.1016/j.humimm.2008.10.004

Genes

MBL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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