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Article

Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation.

Journal of neurochemistry - 1 Dec 2008

Andres Douglas A, Shi Geng-Xian, Bruun Donald, Barnhart Chris, Lein Pamela J

Abstract excerpt

The proinflammatory cytokine interferon-gamma (IFNgamma) alters neuronal connectivity via selective regressive effects on dendrites but the signaling pathways that mediate this effect are poorly understood. We recently demonstrated that signaling by Rit, a member of the Ras family of GTPases, modulates dendritic growth in primary cultures of sympathetic and hippocampal neurons. In this study, we investigated a...

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Identifiers

PMID: 18957053
DOI: 10.1111/j.1471-4159.2008.05708.x
PMCID: PMC2857931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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