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Article

The novel GTPase Rit differentially regulates axonal and dendritic growth.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Apr 2007

Lein Pamela J, Guo Xin, Shi Geng-Xian, Moholt-Siebert Melissa, Bruun Donald, Andres Douglas A

Abstract excerpt

The Rit GTPase is widely expressed in developing and adult nervous systems, and our previous data with pheochromocytoma cells implicate Rit signaling in NGF-induced neurite outgrowth. In this study, we investigated a role for Rit in neuronal morphogenesis. Expression of a dominant-negative (dn) Rit mutant in hippocampal neurons inhibited axonal growth but potentiated dendritic growth. Conversely, a constitutively...

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Source

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Identifiers

PMID: 17460085
DOI: 10.1523/JNEUROSCI.5633-06.2007
PMCID: PMC3495986

Genes

BMP7
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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