Article
Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2007
Furutani Yutaka, Matsuno Hitomi, Kawasaki Miwa, Sasaki Takehiko, Mori Kensaku, Yoshihara Yoshihiro
Abstract excerpt
Dendritic filopodia are long, thin, actin-rich, and dynamic protrusions that are thought to play a critical role as a precursor of spines during neural development. We reported previously that a telencephalon-specific cell adhesion molecule, telencephalin (TLCN) [intercellular adhesion molecule-5 (ICAM-5)], is highly expressed in dendritic filopodia, facilitates the filopodia formation, and slows spine...
Topics
- Actins
- Animals
- Cells, Cultured
- Cytoskeletal Proteins
- DNA-Binding Proteins
- Dendrites
- Diagnostic Imaging
- Embryo, Mammalian
- Hippocampus
- Immunoprecipitation
- Membrane Glycoproteins
- Mice
- Models, Biological