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Article

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.

Biochimica et biophysica acta - 1 Dec 2007

Rudolph Jennifer L, Shi Geng-Xian, Erdogan Eda, Fields Alan P, Andres Douglas A

Abstract excerpt

Rit is a novel member of the Ras superfamily of small GTP-binding proteins that regulates signaling pathways controlling cellular fate determination. Constitutively activated mutants of Rit induce terminal differentiation of pheochromocytoma (PC6) cells resulting in a sympathetic neuron-like phenotype characterized by the development of highly-branched neurites. Rit signaling has been found to activate several...

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Identifiers

PMID: 17976838
DOI: 10.1016/j.bbamcr.2007.09.008
PMCID: PMC2175081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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