Article
Phantom mutation hotspots in human mitochondrial DNA.
Electrophoresis - 1 Sept 2005
Brandstätter Anita, Sänger Timo, Lutz-Bonengel Sabine, Parson Walther, Béraud-Colomb Eliane, Wen Bo, Kong Qing-Peng, Bravi Claudio M, Bandelt Hans-Jürgen
Abstract excerpt
Phantom mutations are systematic artifacts generated in the course of the sequencing process. Contra common belief these artificial mutations are nearly ubiquitous in sequencing results, albeit at frequencies that may vary dramatically. The amount of artifacts depends not only on the sort of automated sequencer and sequencing chemistry employed, but also on other lab-specific factors. An experimental study...
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