Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice.

Brain research - 17 Mar 2006

Elsen Frank P, Liljelund Patricia, Werner David F, Olsen Richard W, Homanics Gregg E, Harrison Neil L

Abstract excerpt

Gamma-aminobutyric acid-type A receptors (GABA(A)-Rs) have been proposed as a target for many general anesthetics. We recently created knockin (KI) mice harboring a point mutation (serine 270 to histidine) in the GABA(A)-R alpha1 subunit. This mutation abolishes sensitivity of recombinant GABA(A)-Rs to isoflurane while maintaining normal sensitivity to halothane and increasing the potency of GABA. KI mice showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroencephalography

Share to Halothane

Share to Isoflurane

Share to Membrane Potentials

Share to Receptors, GABA-A

Share to Seizures

Source

Identifiers

PMID: 16490182
DOI: 10.1016/j.brainres.2006.01.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice.PMID 16490182Read ↗

A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse.Semantic proximity Read ↗

An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.Semantic proximity Read ↗

Genetic manipulations of GABAA receptor in mice make inhibition exciting.Semantic proximity Read ↗

Divergent GABA(A) receptor-mediated synaptic transmission in genetically seizure-prone and seizure-resistant rats.Semantic proximity Read ↗

Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.Semantic proximity Read ↗

Mice harboring the T316N variant in the GABAAR γ2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway.Semantic proximity Read ↗

Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.Semantic proximity Read ↗

GABAA receptor β3 subunit mutation D120N causes Lennox–Gastaut syndrome in knock-in miceSemantic proximity Read ↗

Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus.Semantic proximity Read ↗

Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.Semantic proximity Read ↗

The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy.Semantic proximity Read ↗

Severity of atypical absence phenotype in GABAB transgenic mice is subunit specific.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.