The biophysical characterization of the transcription factor MntR from Mycobacterium tuberculosis and its selected mutants.

doi:10.1016/j.ijbiomac.2026.151718

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Article

The biophysical characterization of the transcription factor MntR from Mycobacterium tuberculosis and its selected mutants.

International journal of biological macromolecules - 1 Apr 2026

Jelić Matošević Zoe, Radman Katarina, Semenić Lana, Neves Rui P P, Brajković Mislav, Crnolatac Ivo, Bubić Ante, Bzowska Agnieszka, Kutrowska Beata Wielgus, Merunka Dalibor, Žilić Dijana, Novak Predrag, Zangger Klaus, Fernandes Pedro Alexandrino, Juranović Cindrić Iva, Bregović Nikola, Piantanida Ivo, Leščić Ašler Ivana, Bertoša Branimir

Abstract excerpt

Protein MntR is a transcription factor regulating Mn2+ homeostasis in Mycobacterium tuberculosis, the causative agent of tuberculosis. A combination of computational (QM, MD, protein-DNA docking) and experimental (AUC, ITC, DSC, EPR, NMR, CD, EMSA) methods was used to characterize wild-type MntR and its selected mutants, as well as its complex with the target DNA sequence. Molecular dynamics simulations revealed...

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PMID: 41916519
DOI: 10.1016/j.ijbiomac.2026.151718

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