The physical frailty syndrome as a transition from homeostatic symphony to cacophony.

Abstract excerpt

Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the aging-related pathophysiology underpinning the clinical presentation of physical frailty as a phenotype of a clinical syndrome that is distinct from the cumulative-deficit-based frailty index. We focus on integrating the...

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• Aged
• Aging
• Frail Elderly
• Frailty
• Homeostasis
• Phenotype