Article
Critical Illness and the Frailty Syndrome: Mechanisms and Potential Therapeutic Targets.
Anesthesia and analgesia - 1 Jun 2020
Paul Jonathan A, Whittington Robert A, Baldwin Matthew R
Abstract excerpt
Frailty is a syndrome characterized by decreased reserves across multiple physiologic systems resulting in functional limitations and vulnerability to new stressors. Physical frailty develops over years in community-dwelling older adults but presents or worsens within days in the intensive care unit (ICU) because common mechanisms governing age-related physical frailty are often exacerbated by critical illness....
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