Article
Association between SREBF2 gene polymorphisms and metabolic syndrome in clozapine-treated patients with schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry - 2 Jan 2015
Yang Lin, Chen Jianhua, Liu Dengtang, Yu Shunying, Cong Enzhao, Li Yan, Wu Haisu, Yue Ying, Zuo Sai, Wang Yan, Liang Shiqiao, Shi Yongyong, Shi Shenxun, Xu Yifeng
Abstract excerpt
BACKGROUND: Patients with schizophrenia using antipsychotics often develop metabolic side effects, especially with clozapine. Previous studies indicated that antipsychotics could activate the pathway of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element binding transcription factor 2 (SREBF2) gene mainly regulates the cholesterol biosynthetic gene. Therefore, we hypothesized that...
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