Article
Variants and expression changes in PPAR-encoding genes display no significant association with schizophrenia.
Bioscience reports - 31 Jul 2020
Li Xinrong, Zhu Yue, Keaton Maria, Baranova Ancha, Liu Sha, Hu Xiaodong, Li Qi, Cheng Long, Zhou Peng, Cao Hongbao, Xu Yong
Abstract excerpt
A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a large cohort genome-wide association study (GWAS). Then, a mega-analysis was conducted using 14...
Topics
- Adolescent
- Age of Onset
- Brain
- Case-Control Studies
- Cohort Studies
- Datasets as Topic
- Female
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Healthy Volunteers
- Humans
- Male