Article
Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?
Molecular psychiatry - 1 Mar 2009
Le Hellard S, Theisen F M, Haberhausen M, Raeder M B, Fernø J, Gebhardt S, Hinney A, Remschmidt H, Krieg J C, Mehler-Wex C, Nöthen M M, Hebebrand J, Steen V M
Abstract excerpt
Atypical antipsychotics are nowadays the most widely used drugs to treat schizophrenia and other psychosis. Unfortunately, some of them can cause major metabolic adverse effects, such as weight gain, dyslipidemia and type 2 diabetes. The underlying lipogenic mechanisms of the antipsychotic drugs are not known, but several studies have focused on a central effect in the hypothalamic control of appetite regulation...
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