Article
Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-α gene (PPARA) and schizophrenia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jul 2013
Costa Marta, Squassina Alessio, Congiu Donatella, Chillotti Caterina, Niola Paola, Galderisi Silvana, Pistis Marco, Del Zompo Maria
Abstract excerpt
Schizophrenia (SZ) is a complex psychiatric disorder with a large genetic burden and an estimated hereditability of 80%. A large number of neuroanatomical and psychopharmacological studies suggest a central role of the endocannabinoid (eCB) system in the susceptibility of the disease. To further investigate this hypothesis, we performed an association study with genes codifying for key elements of the eCB system...
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