Article
Covert preleukemia driven by MLL gene fusion.
Genes, chromosomes & cancer - 1 Jan 2009
Zuna Jan, Burjanivova Tatiana, Mejstrikova Ester, Zemanova Zuzana, Muzikova Katerina, Meyer Claus, Horsley Sharon W, Kearney Lyndal, Colman Susan, Ptoszkova Hana, Marschalek Rolf, Hrusak Ondrej, Stary Jan, Greaves Mel, Trka Jan
Abstract excerpt
Acute leukemia is considered to be a two- or multiple-step process. Although there is a considerable knowledge regarding the character of the "first hit," the nature of the "second hit" remains unanswered in most of the cases including leukemias with MLL gene rearrangement. We demonstrate here a striking sequence of events, which include a covert, protracted preleukemic phase characterized by a dominant...
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