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Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero.

Blood - 1 Aug 1999

Wiemels J L, Ford A M, Van Wering E R, Postma A, Greaves M

Abstract excerpt

We report a pair of identical twins with concordant acute lymphoblastic leukemia (ALL). Unusually, their diagnoses were spaced 9 years apart at ages 5 and 14. Leukemic cells in both twins had a TEL-AML1 rearrangement, which was characterized at the DNA level by an adaptation of a long distance polymerase chain reaction (PCR) method. The genomic fusion sequence was identical in the two leukemias, indicative of a...

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PMID: 10419898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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