Article
Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations.
Blood advances - 28 Dec 2021
Montgomery Nathan D, Galeotti Jonathan, Johnson Steven M, Commander Leah, Weimer Eric T, Chandra Pranil K, Nazir Tariq, Alexander Thomas B, Zeidner Joshua F, Foster Matthew C
Abstract excerpt
Rare hematologic malignancies display evidence of both myeloid and lymphoid differentiation. Here, we describe such a novel bilineal event discovered in an adult woman with B-lymphoblastic leukemia (BLL). At the time of BLL diagnosis, the patient had a normal karyotype and a bulk sequencing panel identified pathogenic variants in BCOR, EZH2, RUNX1, and U2AF1, a genotype more typical of myeloid neoplasia....
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