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Article

Chromosome translocations and covert leukemic clones are generated during normal fetal development

4 Jun 2002

Abstract excerpt

Studies on monozygotic twins with concordant leukemia and retrospective scrutiny of neonatal blood spots of patients with leukemia indicate that chromosomal translocations characteristic of pediatric leukemia often arise prenatally, probably as initiating events. The modest concordance rate for leukemia in identical twins ( approximately 5%), protracted latency, and transgenic modeling all suggest that additional...

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PMID: 12048236
DOI: 10.1073/pnas.112218799

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