Article
SNPs detection by a single-strand specific nuclease on a PNA zip-code microarray.
Biosensors & bioelectronics - 15 Feb 2009
Mun Hyo Young, Girigoswami Agnishwar, Jung Cheulhee, Cho Dae-Yeon, Park Hyun Gyu
Abstract excerpt
In this report, a reliable peptide nucleic acid (PNA) microarray-based method for accurately detecting single nucleotide polymorphism (SNP) in human genes is described. The technique relies on the mismatched cleavage activity of a single-strand specific (SSS) nuclease. PCR amplification was perfo...
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