Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer.

Molecules (Basel, Switzerland) - 12 Feb 2020

Fouz Munira F, Appella Daniel H

Abstract excerpt

This review describes the application of peptide nucleic acids (PNAs) as clamps that prevent nucleic acid amplification of wild-type DNA so that DNA with mutations may be observed. These methods are useful to detect single-nucleotide polymorphisms (SNPs) in cases where there is a small amount of mutated DNA relative to the amount of normal (unmutated/wild-type) DNA. Detecting SNPs arising from mutated DNA can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Neoplasm
Share to Mutation
Share to Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleic Acid Amplification Techniques

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 32059456
DOI: 10.3390/molecules25040786
PMCID: PMC7070360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer.PMID 32059456Read ↗

Single base pair mutation analysis by PNA directed PCR clamping.Semantic proximity Read ↗

Simultaneous genotyping of multiple somatic mutations by using a clamping PNA and PNA detection probes.Semantic proximity Read ↗

PCR clamping.Semantic proximity Read ↗

Detection of tumor mutations in the presence of excess amounts of normal DNA.Semantic proximity Read ↗

Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe.Semantic proximity Read ↗

SNPs detection by a single-strand specific nuclease on a PNA zip-code microarray.Semantic proximity Read ↗

Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping.Semantic proximity Read ↗

Single-nucleotide polymorphism detection using peptide nucleic acids.Semantic proximity Read ↗

High-fidelity DNA polymerase enhances the sensitivity of a peptide nucleic acid clamp PCR assay for K-ras mutations.Semantic proximity Read ↗

PNA-mediated PCR clamping. Applications and methods.Semantic proximity Read ↗

Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnostics.Semantic proximity Read ↗

PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.