Article
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs.
Nucleic acids research - 1 Nov 2008
Soifer Harris S, Sano Masayuki, Sakurai Kumi, Chomchan Pritsana, Saetrom Pål, Sherman Mark A, Collingwood Michael A, Behlke Mark A, Rossi John J
Abstract excerpt
In humans a single species of the RNAseIII enzyme Dicer processes both microRNA precursors into miRNAs and long double-stranded RNAs into small interfering RNAs (siRNAs). An interesting but poorly understood domain of the mammalian Dicer protein is the N-terminal helicase-like domain that possesses a signature DExH motif. Cummins et al. created a human Dicer mutant cell line by inserting an AAV targeting cassette...
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