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Article

Protein-protein interactions involving congenital cataract T5P gammaC-crystallin mutant: a confocal fluorescence microscopy study.

Experimental eye research - 1 Dec 2008

Liu Bing-Fen, Song Shuhua, Hanson Mark, Liang Jack J-N

Abstract excerpt

The human lens crystallin gene CRYGC T5P is associated with Coppock-like cataract and has a phenotype of a dust-like opacity of the fetal lens nucleus and deep cortical region. Previous in vitro mutation studies indicate that the protein has changed conformation, solubility, and stability, which may make it susceptible to aggregation, as seen in cataractous lens and cell culture expression. To investigate the...

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Source

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Identifiers

PMID: 18926820
DOI: 10.1016/j.exer.2008.08.021
PMCID: PMC2644446

Genes

CRYGC
CRYAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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