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Article

Structural and aggregation behavior of the human γD-crystallin mutant E107A, associated with congenital nuclear cataract.

Molecular vision - 17 Dec 2010

Vendra Venkata Pulla Rao, Balasubramanian Dorairajan

Abstract excerpt

PURPOSE: To analyze the conformational features and aggregation properties of the mutant protein E107A human γD-crystallin (HGDC), associated with congenital nuclear cataract. METHODS: cDNAs of wild type and E107A mutant were cloned and expressed in BL21 (DE3) pLysS cells and the proteins isolated and purified. The conformational properties and structural stability of the two proteins were compared using circular...

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PMID: 21197114
PMCID: PMC3008718

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