Article
Interactions and chaperone function of alphaA-crystallin with T5P gammaC-crystallin mutant.
Protein science : a publication of the Protein Society - 1 Sept 2004
Liang Jack J-N
Abstract excerpt
T5P gammaC-crystallin mutation is associated with Coppock-like cataract, one of the autosomal dominant congenital cataracts. It is not known why the abundant alpha-crystallin cannot prevent the mutation-related aggregation. Our previous studies indicate that the mutation changes conformation and reduces solubility and stability, but it is not known whether it is these events or the loss of interaction with other...
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