Article
Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P gamma C-crystallin.
Experimental cell research - 1 Jan 2006
Pigaga Vilius, Quinlan Roy A
Abstract excerpt
The T5P mutation in human gamma C-crystallin produces a lens cataract. Here, we have investigated the effects of the T5P mutation upon the aggregation of gamma C-crystallin in vitro and in transfected cells. By sedimentation assay and sucrose gradient centrifugation, the mutation significantly increased the aggregation of the protein and reduced dramatically its solubility in vitro. Similar effects were seen when...
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