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Article

Conformational change and destabilization of cataract gammaC-crystallin T5P mutant.

FEBS letters - 27 Feb 2002

Fu Ling, Liang Jack J N

Abstract excerpt

Human lens gammaC-crystallin and T5P mutant were cloned, and their biophysical properties and thermodynamic stability were studied. CRYGC (T5P) is one of the many gamma-crystallin mutant genes for autosomal dominant congenital cataracts. This mutation is associated with Coppock-like cataract, and has the phenotype of a dust-like opacity of the fetal lens nucleus. During cloning and overexpression, the majority of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11904153
DOI: 10.1016/s0014-5793(02)02313-x

Genes

CRYGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformational change and destabilization of cataract gammaC-crystallin T5P mutant.PMID 11904153Read ↗

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