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Article

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease.

Genes & development - 15 Oct 2001

Kaliraman V, Mullen J R, Fricke W M, Bastin-Shanower S A, Brill S J

Abstract excerpt

The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase III (Top3) and are thought to act during DNA replication to restart forks that have paused due to DNA damage or topological stress. We have shown previously that yeast cells lacking SGS1 or TOP3 require MMS4 and MUS81 for viability. Here we show that Mms4 and Mus81 form a heterodimeric structure-specific endonuclease that cleaves...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 11641278
DOI: 10.1101/gad.932201
PMCID: PMC312806

Genes

BLM
ERCC1
MUS81

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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