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A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms.

The pharmacogenomics journal - 1 Dec 2009

Gassó P, Mas S, Bernardo M, Alvarez S, Parellada E, Lafuente A

Abstract excerpt

We present a pharmacogenetic study of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS) using an extensive linkage disequilibrium mapping approach in seven-candidate genes with a well-established link to dopamine (DRD2, DRD3, ACE, COMT, DAT, MAO-A, MAO-B). From a cohort of 321 psychiatric inpatients, 81 cases presenting with EPS (Simpson-Angus > 3) and 189 controls presenting without EPS...

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Antipsychotic Agents
Basal Ganglia Diseases
Chromosome Mapping
DRD3 gene
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Receptors, Dopamine D3

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Identifiers

PMID: 19506579
DOI: 10.1038/tpj.2009.26

Genes

DRD3
DRD2
ACE
COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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