Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.

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Article

Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.

Oncogene - 1 Aug 1991

Haddow S, Fowlis D J, Parkinson K, Akhurst R J, Balmain A

Abstract excerpt

The relationship between the expression of a mutant ras gene in epithelial cells and loss of responsiveness to the negative effects of transforming growth factor beta (TGF-beta) is presently unclear. We have investigated this question using a series of cell lines derived from benign and malignant...

Topics

Animals
Cell Division
Cell Transformation, Neoplastic
DNA, Neoplasm
Epithelium
Gene Expression Regulation, Neoplastic
Genes, ras
Mice
Mutation
Skin Neoplasms
Thymidine
Transcriptional Activation
Transforming Growth Factor beta
Tritium
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1886717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1886717-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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