Article
Mitochondrial 12S rRNA susceptibility mutations in aminoglycoside-associated and idiopathic bilateral vestibulopathy.
Biochemical and biophysical research communications - 12 Dec 2008
Elstner M, Schmidt C, Zingler V C, Prokisch H, Bettecken T, Elson J L, Rudolph G, Bender A, Halmagyi G M, Brandt T, Strupp M, Klopstock T
Abstract excerpt
The mitochondrial 12S rRNA is considered a hotspot for mutations associated with nonsyndromic (NSHL) and aminoglycoside-induced hearing loss (AIHL). Although aminoglycoside ototoxicity is the most common cause of bilateral vestibular dysfunction, the conceivable role of 12S rRNA mutations has never been systematically investigated. We sequenced the 12S rRNA of 66 patients with bilateral vestibulopathy (BV) with...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aminoglycosides
- Anti-Bacterial Agents
- Base Sequence
- Conserved Sequence
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Mutation