Article
Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2.
Development (Cambridge, England) - 1 Nov 2008
Yasuhiko Yukuto, Kitajima Satoshi, Takahashi Yu, Oginuma Masayuki, Kagiwada Harumi, Kanno Jun, Saga Yumiko
Abstract excerpt
The T-box transcription factor Tbx6 controls the expression of Mesp2, which encodes a basic helix-loop-helix transcription factor that has crucial roles in somitogenesis. In cultured cells, Tbx6 binding to the Mesp2 enhancer region is essential for the activation of Mesp2 by Notch signaling. However, it is not known whether this binding is required in vivo. Here we report that an Mesp2 enhancer knockout mouse...
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