Article
Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement.
Mechanisms of development - 1 Jul 1998
Saga Y
Abstract excerpt
Gene knock-out and knock-in strategies are employed to investigate the function of MesP1. MesP1 belongs to the same family of bHLH transcription factors as MesP2. The early expression pattern observed in the early mesoderm at the onset of gastrulation is restricted to Mesp1, while the later expre...
Topics
- Abnormalities, Multiple
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Bone and Bones
- Cells, Cultured
- Embryonic and Fetal Development
- Female
- Fetal Proteins
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genes
- Head
- Heart
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mesoderm
- Mice