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Article

Location trumps length: polyglutamine-mediated changes in folding and aggregation of a host protein.

Biophysical journal - 8 Jun 2011

Tobelmann Matthew D, Murphy Regina M

Abstract excerpt

Expanded CAG diseases are progressive neurodegenerative disorders in which specific proteins have an unusually long polyglutamine stretch. Although these proteins share no other sequence or structural homologies, they all aggregate into intracellular inclusions that are believed to be pathological. We sought to determine what impact the position and number of glutamines have on the structure and aggregation of...

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Identifiers

PMID: 21641323
DOI: 10.1016/j.bpj.2011.04.028
PMCID: PMC3117178

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