Article
A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men.
Basic research in cardiology - 1 Nov 2008
Adamzik Michael, Frey Ulrich H, Bitzer Kathrin, Jakob Heinz, Baba Hideo A, Schmieder Roland E, Schneider Markus P, Heusch Gerd, Peters Jürgen, Siffert Winfried
Abstract excerpt
BACKGROUND: The family of aquaporin water channels contributes to water and salt homeostasis. AQP5 is a ubiquitously expressed exocrine-type water channel. Functional single nucleotide polymorphisms in AQP5 which alter gene transcription have not yet been described. We, therefore, sequenced the human AQP5 promoter to detect novel sequence variants which could impact upon AQP5 expression and contribute to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.