Article
Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension.
BMC medical genetics - 20 Jan 2005
Hannila-Handelberg Tuula, Kontula Kimmo, Tikkanen Ilkka, Tikkanen Tuula, Fyhrquist Frej, Helin Karri, Fodstad Heidi, Piippo Kirsi, Miettinen Helena E, Virtamo Jarmo, Krusius Tom, Sarna Seppo, Gautschi Ivan, Schild Laurent, Hiltunen Timo P
Abstract excerpt
BACKGROUND: Rare mutations of the epithelial sodium channel (ENaC) result in the monogenic hypertension form of Liddle's syndrome. We decided to screen for common variants in the ENaC beta and gamma subunits in patients with essential hypertension and to relate their occurrence to the activity of circulating renin-angiotensin-aldosterone system. METHODS: Initially, DNA samples from 27 patients with low renin/low...
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