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Article

A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins.

Bioorganic & medicinal chemistry letters - 15 Nov 2008

Brustad Eric, Bushey Mark L, Brock Ansgar, Chittuluru Johnathan, Schultz Peter G

Abstract excerpt

A mutant Escherichia coli leucyl-tRNA synthetase has been evolved for the selective incorporation of the methionine homolog 1 into proteins in yeast. This single aminoacyl-tRNA synthetase is capable of charging an amber suppressor EctRNA(CUA)(Leu) with at least eight different amino acids including methionine and cysteine homologs, as well as straight chain aliphatic amino acids. In addition we show that...

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Identifiers

PMID: 18845434
DOI: 10.1016/j.bmcl.2008.09.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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